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Fioretos' Research Group

Translating genomic discoveries into improved clinical decision making, mechanistic understanding, and therapy of acute leukemia

The overall objective of our research is to significantly improve the way in which acute leukemia is diagnosed, understood at the functional/molecular level, and treated within health care.
We work in three highly aligned and synergistic projects. In the first, new and clinically important genetic changes are identified prospectively in acute leukemia using integrative sequencing and key findings are translated into improved clinical decision making. In the second project, newly identified genetic changes are functionally studied to delineate mechanisms underlying leukemia development. The third project is focused on identifying targets affecting leukemia stem cells and on providing in vivo proof of concept data for targeted therapies with a focus on antibody-based strategies.



Thoas 4

To achieve our objectives, we use start of the art next-generation sequencing technologies, in vitro and in vivo models of acute leukemia, cell sorting, single-cell sequencing and advanced bioinformatics. Our research group collaborates with several international and national research groups, including clinical departments at the university hospital to implement key findings in healthcare. We also have a strong track-record in generating innovations forming the basis for the establishment of new companies.

Five selected recent publications:

For a full list of publications, see the following link:


Our research is mainly funded by the The Swedish Cancer Society, The Swedish Children's Cancer Foundation, The Swedish Research Council (VR), ALF grant for clinical research, Region Skåne, and a Wallenberg Clinical Scholar Award by The Knut and Alice Wallenberg Foundation.

Networks in Academia:

Lund University Cancer Center
Genomics Medicine Sweden 
Center for Translational Genomics

Spin-out companies established based on our research:

Qlucore AB 
Cantargia AB

Link to the research database 

Thoas Fioretos

Thoas Fioretos
Professor, MD, PhD
Department of Laboratory Medicine
Division of Clinical Genetics
Klinikgatan 28
SE-221 84 Lund
Tel. +46 46-222 45 95
Email: Thoas [dot] Fioretos [at] med [dot] lu [dot] se (Thoas[dot]Fioretos[at]med[dot]lu[dot]se)

Research group members:

rasmus [dot] henningsson [at] med [dot] lu [dot] se (Rasmus Henningsson), Postdoc
niklas [dot] landberg [at] med [dot] lu [dot] se (Niklas Landberg), MD, Doctoral student
henrik [dot] lilljebjorn [at] med [dot] lu [dot] se (Henrik Lilljebjörn,) PhD, Ass researcher, Head bioinformatics 
christina [dot] orsmark_pietras [at] med [dot] lu [dot] se (Christina Orsmark Pietras), PhD, Ass researcher
pablo [dot] pena [at] med [dot] lu [dot] se (Pablo Pena), PhD, Research engineer
noelia [dot] puente_moncada [at] med [dot] lu [dot] se (Noelia Puente Moncada), PhD, Postdoc fellow
marianne [dot] rissler [at] med [dot] lu [dot] se (Marianne Rissler), Research engineer
carl [dot] sanden [at] med [dot] lu [dot] se (Carl Sandén), PhD, Ass researcher
hanna [dot] thorsson [at] med [dot] lu [dot] se (Hanna Thorsson), Doctoral student
Helena [dot] Agerstam [at] med [dot] lu [dot] se (Helena Ågerstam,) MD, Ass researcher