Search Results

https://www.clinicalgenetics.lu.se/department-clinical-genetics-0- 2019-01-29

By anette [dot] welin [at] med [dot] lu [dot] se (Anette Welin) - published 19 February 2021 Saba K et al. The Journal of Pathology Clinical Research 2020:6:231-237 Loss of NF2 defines a genetic subgroup of non-FOS-rearranged osteoblastoma…

https://www.clinicalgenetics.lu.se/article/saba-k-et-al-journal-pathology-clinical-research-20206231-237- 2021-02-19

Published 19 February 2021 Clonal competition within complex evolutionary hierarchies shapes AML over time

https://www.clinicalgenetics.lu.se/article/sanden-et-al-nature-communications-202011579-0- 2021-02-19

Published 19 February 2021 CXCR4 Signaling Has a CXCL-12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia

https://www.clinicalgenetics.lu.se/article/ramakrishnan-r-et-al-cell-reports-2020318-0- 2021-02-19

By anette [dot] welin [at] med [dot] lu [dot] se (Anette Welin) - published 10 March 2021 Sister chromatid cohesion defects are associated with chromosomal copy number heterogeneity in high hyperdiploid childhood acute lymphoblastic…

https://www.clinicalgenetics.lu.se/article/moura-castro-lh-et-al-genes-chromosomes-cancer-press- 2021-03-10

By anette [dot] welin [at] med [dot] lu [dot] se (Anette Welin) - published 27 May 2021 IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation. Pablo Peña-Martínez, Ramprasad Ramakrishnan, Carl Högberg,…

https://www.clinicalgenetics.lu.se/article/pablo-pena-martinez-et-al-haematologica-2021-epub-ahead-print- 2021-10-08

By anette [dot] welin [at] med [dot] lu [dot] se (Anette Welin) - published 5 October 2021 DEVOLUTION-A method for phylogenetic reconstruction of aneuploid cancers based on multiregional genotyping data Natalie Andersson, Subhayan…

https://www.clinicalgenetics.lu.se/article/andersson-n-et-al-commun-biol-411103- 2021-10-08

By anette [dot] welin [at] med [dot] lu [dot] se (Anette Welin) - published 8 October 2021 Tracing the evolution of aneuploid cancers by multiregional sequencing with CRUST Subhayan Chattopadhyay, Jenny Karlsson, Anders Valind, Natalie…

https://www.clinicalgenetics.lu.se/article/chattopadhyay-et-al-brief-bioinform-bbab292- 2021-10-08

 The immune system has a remarkable capacity to scan tissues to recognize and eliminate abnormal and malignant cells. Scientific advances now allow us to improve and utilize this strength of the immune system against tumors.Our goal is to…

https://www.clinicalgenetics.lu.se/axel-hyrenius-wittsten- 2024-02-27

https://www.clinicalgenetics.lu.se/startsidan- 2019-02-21

https://www.clinicalgenetics.lu.se/department-clinical-genetics-1- 2019-01-29

Translating genomic discoveries into improved clinical decision making, mechanistic understanding, and therapy of acute leukemia The overall objective of our research is to significantly improve the way in which acute leukemia is diagnosed…

https://www.clinicalgenetics.lu.se/division-clinical-genetics/fioretos-research-group- 2024-02-27

  With a basis in stem cell biology, genetics, immunology and cancer, the major goal of our research is to develop new immunotherapies that target leukemia and other malignancies. To achieve this goal, we work on the following projects:•  …

https://www.clinicalgenetics.lu.se/division-clinical-genetics/jaras-research-group- 2024-03-07

  We focus on understanding the pathogenetic mechanisms underlying leukemogenesis with a special focus on infant leukemia. In particular we are interested in unravelling the biological mechanisms that drive clonal evolution, the emergence…

https://www.clinicalgenetics.lu.se/division-clinical-genetics/anna-hagstrom- 2024-03-11

    We make genetic and functional maps of cancer cell evolution in patients by analysing multiple tumour samples from the same patient. In particular, we focus on childhood cancer where we try to unravel the genetic mechanisms leading to…

https://www.clinicalgenetics.lu.se/division-clinical-genetics/cancer-cell-evolution- 2024-02-27

The Database of Chromosome Aberrations and Gene Fusions in Cancer, established in 1980, is an attempt to register systematically all published cytogenetic aberrations reported in cancer, including patient and tumor characteristics, gene…

https://www.clinicalgenetics.lu.se/division-clinical-genetics/database-chromosome-aberrations-and-gene-fusions-cancer- 2024-03-12

  Soft tissue tumors (STT) constitute a heterogeneous group of approximately 100 distinct neoplasms, including more than 50 malignant subtypes, so-called sarcomas. Genetic analyses have shown that the clinical and biological variation…

https://www.clinicalgenetics.lu.se/division-clinical-genetics/genetics-soft-tissue-tumors- 2024-04-09

The goal of our research is to increase our understanding of the leukemogenic process and to investigate the clinical impact of genetic/epigenetic abnormalities in pediatric acute lymphoblastic and myeloid leukemia. In order to achieve…

https://www.clinicalgenetics.lu.se/division-clinical-genetics/geneticsepigenetics-pediatric-leukemia- 2022-06-03

   Gains and losses of whole chromosomes, termed aneuploidy, is seen in at least half of all tumors. How it affects tumorigenesis is still poorly understood. We use hyperdiploid (51-67 chromosomes) pediatric acute lymphoblastic leukemia …

https://www.clinicalgenetics.lu.se/division-clinical-genetics/aneuploidy-cancer- 2024-03-12

Fig. 1. The highly complex genome of an osteosarcoma.Our aim is to develop new treatment strategies for patients with highly aggressive malignancies. To this end, we screen clinical tumor material for disease-causing mutations using deep…

https://www.clinicalgenetics.lu.se/division-clinical-genetics/complex-genomes-cancer- 2024-03-07